社团学姐漫画

2017.8 -- 2022.6 哈佛大学，化学与化学生物学系，博士

2013.9 -- 2017.6 北京大学，化学与分子工程学院，学士

2026.3 -- 至今 社团学姐漫画 ，长聘教轨副教授

2022.8 -- 2026.1 加州大学旧金山分校，博士后

主要聚焦基于蛋白质的化学生物学，包括利用邻近标记技术和定量质谱结合研究蛋白互作网络，利用光亲和反应和蛋白化学反应研究小分子机理等。

近五年代表工作：

1.     Zhi Lin, Kaitlin Schaefer, Irene Lui, Zi Yao, Andrea Fossati, Danielle L. Swaney, Ajikarunia Palar, Andrej Sali, James A. Wells†. Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells. Science, 2024, 385, eadl5763. DOI:10.1126/science.adl576

2.     Zhi Lin, Wayne Ngo, Yu-Ting Chou, Harry Wu, Katherine J Susa, Young-wook Jun, Trever G Bivona, Jennifer A Doudna, James A Wells†. Temporal photo-proximity labeling of ligand-activated EGFR neighborhoods via MultiMap. Nat. Chem. Biol., 2026, 22，192-204. DOI: 10.1038/s41589-025-02076-y

4.     Zhi Lin*, Yuka Amako*, Farah Kabir, Hope A. Flaxman, Bogdan Budnik, Christina M. Woo†. Development of photolenalidomide for cellular target identification. J. Am. Chem. Soc., 2022, 144, 606-614. (*equal contribution) DOI: 10.1021/jacs.1c11920

3.     Zhi Lin, Dacheng Shen, Bo Yang, Christina M. Woo†. Molecular and structural characterization of lenalidomide-mediated sequestration of eIF3i. ACS Chem. Biol., 2022, 17, 3229-3237. DOI: 10.1021/acschembio.2c00706

5.     Kevin K. Leung*, Kaitlin Schaefer*, Zhi Lin*, Zi Yao*, James A. Wells†. Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome. Chem. Rev., 2025. (*equal contribution) DOI: 10.1021/acs.chemrev.4c00554

6.     Zhi Lin, Christina M. Woo†. Methods to characterize and discover molecular degraders in cells. Chem. Soc. Rev., 2022, 51, 7115-7137. DOI: 10.1039/D2CS00261B

其他工作：

1.     Samuel I. Mann†, Zhi Lin, Jiaqi Zhu, Sophia K. Tan, Ian Bakanas, Jarrett P. Mansergh, Zachary X. W. Widel, Mark J. S. Kelly, Yibing Wu†, James A. Wells†, Michael J. Therien†, William F. DeGrado†. De novo design of proteins that bind naphthalenediimides, powerful photooxidants with tunable photophysical properties. J. Am. Chem. Soc., 2025, 147, 7849-7858. DOI: 10.1021/jacs.4c18151

2.Wayne Ngo, Julia T. Peukes, Alisha Baldwin, Zhiwei Wayne Xue, Sidney Hwang, Robert R. Stickels, Zhi Lin, Ansuman T. Satpathy, James A. Wells, RandySchekman, Eva Nogales, Jennifer A. Doudna†. Mechanism-guided engineering of a minimal biological particle for genome editing. PNAS., 2025, 22, e2413519121. DOI: 10.1073/pnas.2413519121

3.Yuka Amako, Saki Ichikawa, Hannah C. Lloyd, N. Connor Payne, Zhi Lin, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Qian Zhu, Bogdan Budnik, Ralph Mazitschek, Christina M. Woo†. The contribution of cyclic imide stereoisomers on cereblon-dependent activity. Chem. Sci., 2025. DOI: 10.1039/D5SC01371B

4.     Johannes Morstein, Yue Yang, Micah Fernando, Lawrence Zhu, Victoria Bowcut, Meredith L. Jenkins, John T. Evans, Keelan Z. Guiley, D. Matthew Peacock, Sophie Kranke, Zhi Lin, Katya Taran, Ziyang Zhang, Benjamin Huang, Andrew G. Stephen, John E. Burke, Felice C. Lightstone, Kevan M. Shokat†. Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell, 2024, 187, 6379-6392. DOI: 10.1016/j.cell.2024.08.017

5.     Weizhi Yu, Zhi Lin, Christina M. Woo, Jeremy M. Baskin†. A chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions. ACS Chem. Biol., 2022, 17, 3276-3283. DOI: 10.1021/acschembio.1c00584

6.     Johnny H. Hu, Shannon M. Miller, Maarten H. Geurts, Weixin Tang, Liwei Chen, Ning Sun, Christina M. Zeina, Xue Gao, Holly A. Rees, Zhi Lin, David R. Liu†. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. Nature, 2018, 556, 57-63. DOI: 10.1038/nature26155

长期招收博士后、博士生、硕士生和本科生：

请联系[email protected]，建议附上CV和代表作（若有），欢迎对化学、化学生物学、生物、医学、生信及其他交叉方向感兴趣的同学加入，做有意思的科研！